Dual Responsive, Stabilized Nanoparticles for Efficient In Vivo Plasmid Delivery
نویسندگان
چکیده
منابع مشابه
Enzyme-responsive destabilization of stabilized plasmid-lipid nanoparticles as an efficient gene delivery.
Stabilized plasmid-lipid particles (SPLPs) have been developed to overcome the low stability issue of cationic liposomes, however, SPLPs that are too stable result in unsatisfactory transfection efficiency. In this article, we prepared enzyme-responsive SPLPs (eSPLPs) composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and mPEG-GLF...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2013
ISSN: 0044-8249
DOI: 10.1002/ange.201301896